* = equal contribution.
Mobility network modeling explains higher SARS-CoV-2 infection rates among disadvantaged groups and informs reopening strategies
Serina Y Chang*, Emma Pierson*, Pang Wei Koh*, Jaline Gerardin, Beth Redbird, David Grusky, and Jure Leskovec
We develop epidemiological models on top of dynamic mobility networks, derived from US cell phone data, that capture the hourly movements of millions of people from local neighborhoods to points of interest such as restaurants, grocery stores, or religious establishments. These models enable fine-grained analysis of disease spread: among other results, we explain the disparity in SARS-CoV-2 infection rates among disadvantaged racial and socioeconomic groups.
Concept bottleneck models
Pang Wei Koh*, Thao Nguyen*, Yew Siang Tang*, Steve Mussmann, Emma Pierson, Been Kim, and Percy Liang
We revisit learning models that first predict concepts (e.g., the presence of a bone spur) and then the label. This enables interaction in terms of these high-level, human-provided concepts. For example, we can ask: would the model have predicted severe arthritis if it thought there was a bone spur in the x-ray?
An investigation of why overparameterization exacerbates spurious correlations
Shiori Sagawa*, Aditi Raghunathan*, Pang Wei Koh*, and Percy Liang
We analyze why increasing model size can actually hurt model accuracy on minority groups, even though larger models are known to improve average accuracy.
ExpBERT: Representation engineering with natural language explanations
Shikhar Murty, Pang Wei Koh, and Percy Liang
We use natural language explanations to specify high-level inductive biases like "Couples who go on honeymoons are married", and show that it improves accuracy and data efficiency on relation extraction tasks.
Toward trustworthy AI development: Mechanisms for supporting verifiable claims
Miles Brundage*, Shahar Avin*, Jasmine Wang*, Haydn Belfield*, Gretchen Krueger*, Gillian Hadfield, Heidy Khlaaf, Jingying Yang, Helen Toner, Ruth Fong, Tegan Maharaj, Pang Wei Koh, Sara Hooker, ..., Thomas Krendl Gilbert, Lisa Dyer, Saif Khan, Yoshua Bengio, and Markus Anderljung
A multi-institution survey of approaches for increasing trust and verifiability in AI systems.
Distributionally robust neural networks for group shifts: On the importance of regularization for worst-case generalization
Shiori Sagawa*, Pang Wei Koh*, Tatsunori B. Hashimoto, and Percy Liang
Overparameterized neural networks can be highly accurate on average yet consistently fail on atypical groups of the data (e.g., by learning spurious correlations that hold on average but not in such groups). We show that regularization is critical for worst-group performance in overparameterized models, even if it is not needed for average performance. By coupling strong regularization with distributionally robust optimization, we can learn models that attain substantially higher worst-group accuracies.
On the accuracy of influence functions for measuring group effects
Pang Wei Koh*, Kai-Siang Ang*, Hubert H. K. Teo*, and Percy Liang
Influence functions are based on a first-order Taylor approximation that is accurate for sufficiently small changes to the model. However, we often want to study the effects of removing large groups of training points, which can result in significant changes to the model. Surprisingly, we find that on many real-world datasets the influence approximation for groups is still strikingly accurate.
Temporal FiLM: Capturing long-range sequence dependencies with feature-wise modulations
Sawyer Birnbaum*, Volodymyr Kuleshov*, S. Zayd Enam, Pang Wei Koh, Stefano Ermon
We introduce a deep neural network architecture that captures long-range dependencies in sequential inputs, and apply it to the problems of text classification, audio super-resolution, and the enhancement of functional genomics assays.
Inferring multi-dimensional rates of aging from cross-sectional data
Emma Pierson*, Pang Wei Koh*, Tatsunori B. Hashimoto*, Daphne Koller, Jure Leskovec, Nicholas Eriksson, and Percy Liang
We study how individuals change over time given only cross-sectional data, i.e., a single observation per person. While this task is impossible in general, we give assumptions under which we can correctly learn a model from cross-sectional data, and demonstrate our method on the UK Biobank human health dataset.
Stronger data poisoning attacks break data sanitization defenses
Pang Wei Koh*, Jacob Steinhardt*, and Percy Liang
Machine learning models can be corrupted by data poisoning attacks that inject malicious points into the models' training sets. We develop three new data poisoning attacks that can break data sanitization defenses, including commonly-used anomaly detectors based on nearest neighbors, training loss, and singular-value decomposition. Our results underscore the urgent need to develop more sophisticated and robust defenses against data poisoning attacks.
Certified defenses for data poisoning attacks
Jacob Steinhardt*, Pang Wei Koh*, and Percy Liang
Can we bound the worst-cass loss that a defender suffers against any data poisoning attack? We construct approximate upper bounds on the loss across a broad family of attacks for defenders that first perform outlier removal followed by empirical risk minimization. We also introduce an attack that nearly realizes the bound, giving us a powerful tool for quickly assessing defenses on a given dataset.
Understanding black-box predictions via influence functions
Pang Wei Koh and Percy Liang
How can we explain the predictions of a black-box model? We use influence functions--a classic technique from robust statistics--to trace a model's prediction through the learning algorithm and back to its training data, identifying the points most responsible for a given prediction. Influence functions can be used to understand model behavior, debug models and detect dataset errors, and even identify and exploit vulnerabilities to training-set attacks.
Localized hepatic lobular regeneration by central-vein-associated lineage-restricted progenitors
Jonathan M. Tsai, Pang Wei Koh, Ania Stefanska, Liujing Xing, Graham G. Walmsley, Nicolas Poux, Irving L. Weissman, and Yuval Rinkevich
Proceedings of the National Academy of Sciences (PNAS) 2017
An adult liver can eventually recover organ mass after suffering acute tissue loss, but its morphology and architecture will be permanently damaged. We identify a specific time window after birth where the injured lobe can regenerate and become indistinguishable from normal ones. These results hint at a therapeutic window in which specific cells can undergo clonal expansion to give rise to normal structure and function in the face of injury.
An atlas of transcriptional, chromatin accessibility, and surface marker changes in human mesoderm development
Pang Wei Koh*, Rahul Sinha*, Amira A. Barkal, Rachel M. Morganti, Angela Chen, Irving L. Weissman, Lay Teng Ang, Anshul Kundaje, and Kyle M. Loh
Scientific Data 2016
We study the dynamics of translation, chromatin accessibility, and surface markers as pluripotent stem cells differentiate through mesoderm intermediates into bone, heart, and other cell types. As a companion to the biology-focused Cell paper below, this paper focuses on data processing, quality control, and computational analysis.
A comprehensive roadmap from pluripotency to human bone, heart and other mesoderm cell types
Kyle M. Loh, Angela Chen, Pang Wei Koh, Tianda Z. Deng, Rahul Sinha, Jonathan M. Tsai, Amira A. Barkal, Kimberle Y. Shen, Rajan Jain, Rachel M. Morganti, Ng Shyh-Chang, Nathaniel B. Fernhoff, Benson M. George, Gerlinde Wernig, Rachel E.A. Salomon, Zhenghao Chen, Hannes Vogel, Jonathan A. Epstein, Anshul Kundaje, William S. Talbot, Philip A. Beachy, Lay Teng Ang, and Irving L. Weissman
We chart a developmental roadmap that allows us to differentiate pluripotent stem cells into twelve mesodermal lineages, including bone, muscle, and heart. We use this system to produce pure populations of human bone and heart progenitors that successfully engraft in in vivo mouse models, as well as study previously-unobservable events in human embryonic development such as somite segmentation.
Denoising genome-wide histone ChIP-seq with convolutional neural networks
Pang Wei Koh*, Emma Pierson*, and Anshul Kundaje.
Intelligent Systems for Molecular Biology (ISMB) / Bioinformatics 2017
Can we use the structure in biological data to remove noise? On chromatin immunoprecipitation sequencing (ChIP-seq) experiments for histone modifications, we show that a convolutional neural network trained on matching pairs of noisy and high-quality data can significantly improve data quality. Our approach is applicable to biological problems where it is relatively easy to generate noisy versions of high-quality data, but difficult to analytically characterize the noise or underlying data distributions.
Dissecting an online intervention for cancer survivors
Zhenghao Chen, Pang Wei Koh, Philip L. Ritter, Kate Lorig, Erin O’Carroll Bantum, and Suchi Saria
Health Education & Behavior 2014
The debilitating effects of cancer can last long after initial treatment, even if the cancer is in remission. To cope with this, cancer survivors have increasingly turned towards online peer support groups. We study how online participation affects downstream health outcomes, with an eye towards being able to better design such peer support groups.
Peer and self assessment in massive online classes
Chinmay Kulkarni, Pang Wei Koh, Huy Le, Daniel Chia, Kathryn Papadopoulos, Justin Cheng, Daphne Koller, and Scott Klemmer
ACM Transactions on Computer-Human Interaction 2013
Can we use peer- and self-assessment in MOOCs to scale up assessment and learning in global classrooms? We analyzed data from the first MOOC to use peer- and self-assessment and showed that these forms of assessment are effective and scalable, with peer grades correlating highly with staff grades. We also experiment with giving graders automatic feedback and using data to design better rubrics.
Identifying genetic drivers of cancer morphology
Pang Wei Koh, Andrew Beck, and Daphne Koller.
Undergraduate honors thesis 2012
Cancer cells have both abnormal morphology and anomalous gene expression. How are morphology and gene expression linked? We extract clinically-relevant features from tumor micrographs and develop new multi-task regression methods to associate these image features with gene expression. We use this method to study data from hundreds of breast cancer patients, deriving testable hypotheses about the effect of specific genes on tumor morphology.
Jiquan Ngiam, Pang Wei Koh, Zhenghao Chen, Sonia Bhaskar, and Andrew Y. Ng
Many algorithms for unsupervised feature learning require either extensive parameter tuning or are unable to scale to large input sizes. We introduce sparse filtering, a simple feature learning method that scales gracefully and has only one parameter to tune.
Learning deep energy models
Jiquan Ngiam, Zhenghao Chen, Pang Wei Koh, and Andrew Y. Ng
We introduce deep energy models, a type of deep generative model which uses several layers of feedforward functions to model the probability distribution of data. Our model admits efficient inference and obtains good generative and classification performance on natural and synthetic image data.
On random weights and unsupervised feature learning
Andrew Saxe, Pang Wei Koh, Zhenghao Chen, Maneesh Bhand, Bipin Suresh, and Andrew Y. Ng
Some feature learning architectures do well on object recognition tasks even when their feature weights are totally untrained and randomized. Why can random weights do so well? We show that certain architectures can be inherently frequency selective and translation invariant, even with random weights. Based on this, we show how random weights can be used to perform extremely fast architecture searches.
Tiled convolutional neural networks
Quoc V. Le, Jiquan Ngiam, Zhenghao Chen, Daniel Chia, Pang Wei Koh, and Andrew Y. Ng
Enforcing strict convolution in neural networks (i.e., where each filter is the same at every location) can be overly restrictive. We propose tiled convolution neural networks that use a regular tiled pattern of tied weights. This flexibility allows us to learn complex invariances and achieve competitive object classification results.
Lower bound on the time complexity of local adiabatic evolution
Zhenghao Chen, Pang Wei Koh, and Zhao Yan
Physical Review A 2006
We present two simple approaches for evaluating the time complexity of local adiabatic evolution using time-independent parameters, which avoids evaluating the entire time-dependent gap function.
At Coursera, we were fortunate to have troves of data on what makes for effective teaching.
I spoke frequently at workshops and conferences about online education
and worked with many instructors on their courses. My team designed
authoring tools and analytics dashboards for our instructors.
In 2012, I was head TA for CS228 at Stanford, Daphne's class on
Probabilistic Graphical Models.
Together with 8 other TAs, we revamped the class to make it
application-focused and auto-gradable, and successfully taught it to 200+ Stanford students
and 100,000+ online learners on the Coursera platform.
Before college, Zhenghao Chen and I created and taught a series of 14 full-day workshops for 100+ high school students, covering introductions to programming, artificial intelligence, cryptography, and computer networking.